Hydroxychloroquine-induced lipidosis of the kidney mimicking Fabry disease: a case report
نویسندگان
چکیده
A 51-year-old female patient with Sjogren’s syndrome had a renal insufficiency after 2 months’ history of hydroxychloroquine therapy (300 mg/d, cumulative dose of about 18 g). The renal biopsy suggested Fabry disease. The gene analysis and plasma a-galactosidase A activity were in the normal range. After quitting the therapy of hydroxychloroquine, the renal function returned to its normal state in the next 3 months’ follow-up.
منابع مشابه
Curvilinear bodies in hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease
Inherited and acquired metabolic disorders are responsible for renal intracellular accumulation of phospholipids. Ultrastructural analysis revealing typical myeloid or zebra bodies was previously thought to be exclusive to Fabry disease. However, chloroquine/hydroxychloroquine toxicity can cause similar abnormalities. Recent studies have mentioned curvilinear bodies (CLB) in renal cells in such...
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